Blood Sugar Regulation

 Blood Sugar Regulation 

The pancreas releases insulin and glucagon (shown here in purple and green) to control blood sugar levels.
Blood sugar levels are a measure of how effectively an individual's body uses glucose. 

illustration of the pancreas releasing insulin and glucagon

When the body does not convert enough glucose for use, blood sugar levels remain high. Insulin helps the body's cells absorb glucose, lowering blood sugar and providing the cells with the glucose they need for energy.

When blood sugar levels are too low, the pancreas releases glucagon. Glucagon forces the liver to release stored glucose, which causes the blood sugar to rise.

Insulin and glucagon are both released by islet cells in the pancreas. These cells are clustered throughout the pancreas. Beta islet cells (B cells) release insulin, and alpha islet cells (A cells) release glucagon.

How insulin works
The body converts energy from carbohydrates into glucose. The body's cells need glucose for energy, but most cells cannot directly use glucose.

Insulin acts like a key to allow glucose to access the cells. It attaches to insulin receptors on cells throughout the body, telling those cells to open up and allow glucose to enter.

Low levels of insulin are constantly circulating throughout the body. When insulin rises, this signals to the liver that blood glucose is also high. The liver absorbs glucose, then changes it to a storage molecule called glycogen.

When blood sugar levels drop, glucagon signals the liver to convert the glycogen back to glucose. This makes blood sugar levels go up.

Insulin also supports healing after an injury by delivering amino acids to the muscles. Amino acids help build the protein found in muscle tissue, so when insulin levels are low, muscles may not heal properly.

How glucagon works
The liver must store glucose to power the cells during times of low blood sugar. Skipping meals and poor nutrition can lower blood sugar. By storing glucose, the liver makes sure blood glucose levels stay steady between meals or during sleep.

When blood glucose falls, cells in the pancreas secrete glucagon. Glucagon instructs the liver to convert glycogen to glucose. This makes glucose more available in the bloodstream. From there, insulin attaches to insulin receptors on cells to make sure they can absorb glucose.

Insulin and glucagon work in a cycle. Glucagon interacts with the liver to raise blood sugar, while insulin lowers blood sugar by helping the cells to use glucose.

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